- Worms (acquired by close proximity to infected machinery/enemies)
- Corrupt robotic assets (UAC robots or supply drones) the Slayer encounters
- Jam automap
- Jam HUD
- Viruses (require physical interaction with infected machinery/enemies)
- Disable ammo fabricators
- Disable armor fabricators
- Disable equipment items/tools
- Disable Harmonic Resonators (set heavy metal volume to 0)
- Disable power-ups
Mars (UAC)
- Ammo crates (restore all of Slayer's common ammo)
- Arena portals
- ATLAS shield batteries (powerful explosive/electric)
- Breakable walls/doors
- Coolant tanks (freeze enemies, briefly slow Slayer)
- Destructible platforms (usually over lava or nukage)
- Explosive barrels (presumed to contain Argent, damage Slayer and demons)
- Exposed wiring (can be shot to produce electric surge)
- Flame vents (from broken gas pipes; can be continuous or periodic)
- Gressen generators (gravity field generators; enable Earth-like gravity inside Mars Base)
- Health Station
- Industrial capacitors (electric barrels; do no damage but electrify enemies)
- Jump pads (malfunctioning gravity panels or DynoPhasic gravity elevators)
- Laser gates/grids
- Map stations
- Molten metal (harms both demons and the Slayer)
- Nuclear bombshell (tactical nukes, serve as "nuclear" explosive barrels)
- Nukage (corrosive/radioactive liquid waste; harmful to demons but harmless to the Slayer)
- Nukage barrels
- Plasma emitters (emit damaging surge across small area; can be mounted on floor or walls; can be continuous or periodic)
- Quick-deploy droid stations
- Psionic emitters (can be hijacked via relay terminals; can be used both by Slayer and Rambler Griefers to transmit psionic frequencies to distress opponents)
- Reinforced walls (in Lazarus Labs; highly resistant to damage; restrict the Slayer but not phase-shift-capable enemies)
- Security turrets (machine guns that deploy from ceiling to prevent unauthorized access)
- Teleporters
- Test-firing rocket engines (in Spaceport only)
Mars (natural)
- Dust storms (reduce visibility; boost electric attacks and raise chance of lightning strikes)
- Low gravity outside of Base
- Lightning strikes (damage and hitstun)
- Sand (shoot to raise obscuring dust plume)
Mars (demonic)
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- Backdoor (construct in shape of door, injects demonic malware when interacted with)
- Blackout Drone (produces cloud of metallic particles that obscures all light/sound in room; doesn't affect Clearsight)
- Blood Drone (corrupt supply drone; restores ammo but at cost of HEALTH)
- Cloak Drone (conceals single demon in cloaking field)
- CRTerror (fills area with rising audiovisual static; explode when destroyed)
- Cursed darkness (seen in Lazarus Labs - greatly reduces ambient light)
- Cyber Nest (cyborg Gore Nest; injects malware virus when destroyed)
- Demonic malware
- Dust Devils
- Evil Eyes (drains life and fills vision with hellish symbols when in their line-of-sight)
- Fireblu Torches (blind whenever in own field-of-view)
- Gore Nest
- Hellgrowth
- Portal Drone (follows Slayer and constantly transports demons closer to him)
- Suicide Drone (corrupt supply drone; explodes when interacted with for damage)
- Trojan Drone (corrupt supply drone; injects demonic malware when interacted with)
- Virus Drone (corrupt supply drone; kamikazes Slayer when sighted to explode and deliver demonic malware)
Hell (natural)
- Acid lakes (replace nukage)
- Blood Storm (highly corrosive metallic rains)
- Breakable floor over chasms/lava/spikes (shoot to break and drop demons)
- Collapsible stone columns (topple by Rampaging into them, crushing demons they fall onto)
- Crystal obelisks (topple by shooting at base, crushing demons they fall onto)
- Crystal spikes (impale enemies thrown onto them)
- Gas vents (lift/jump pads)
- Firestorm (incendiary storm)
- Lava lakes/rivers/falls (harms both demons and the Slayer)
- Shockspires (floating rock spikes energized with red electricity; hit with stun bomb to short out and release strong shockwave)
- Stalactites (topple by shooting at base, crushing demons they fall onto)
- Tyrant Star (damages whenever are caught in its scorching rays; must take cover within shadows)
Hell (artificial)
- Crusher ceilings/pillars
- Hellstorm Pylon (perimeter cannons defending Hell fortresses)
- Hive Nexus (demonic map station)
- Sentinel Bonfires (resting place of fallen Sentinel warriors, laid to rest by Slayer; restore Slayer's health)